Time-Dependent Disruption of Oviduct Pacemaker Cells by Chlamydia Infection in Mice1

Chlamydia Infection in Murine Oviduct Epithelial Cells

Identifying a Role for TLR3 in the Innate Immune Response to 1 Chlamydia Infection in Murine Oviduct Epithelial Cells 2 3 Wilbert A. Derbigny†, LaTasha R. Shobe, Jasmine C. Kamran, Katherine S. Toomey, and 4 Susan Ofner 5 Department of Microbiology and Immunology, Department of Medicine, Department of 6 Biostatistics; Indiana University School of Medicine 7 Indianapolis, Indiana 46202 8 9 10 11...

The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.

Epithelial cells lining the murine genital tract act as sentinels for microbial infection, play a major role in the initiation of the early inflammatory response, and can secrete factors that modulate the adaptive immune response when infected with Chlamydia. C. muridarum-infected murine oviduct epithelial cells secrete the inflammatory cytokines IL-6 and GM-CSF in a TLR2-dependent manner. Furt...

The Chlamydia muridarum-Induced IFN-b Response Is TLR3-Dependent in Murine Oviduct Epithelial Cells

Expression of CXCR3 on Adaptive and Innate Immune Cells Contributes Oviduct Pathology throughout Chlamydia muridarum Infection

CXCR3 is a chemokine receptor expressed on a wide range of leukocytes, and it is involved in leukocyte migration throughout the blood and lymphatics. Specifically, CXCR3 is required for lymphocyte homing to the genital mucosa. When compared to wild type (WT) mice, CXCR3 deficiency (CXCR3-/-) mice infected with Chlamydia muridarum (C. muridarum) did not display impaired clearance and resolution ...

Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines.

Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the United States and a major cause of female infertility due to infection-induced Fallopian tube scarring. Epithelial cells are likely central to host defense and pathophysiology as they are the principal cell type productively infected by C. trachomatis. We generated cloned murine oviduct epithelial cell lines ...